Review ArticleOpen Access

The Effects of Exogenous Modulation on the Peripheral Nerve Regeneration after Injury and Primary Surgical Repair

Volume 4 - Issue 3

**Emilia Manole*^1,2, Alexandra Bastian^2,3,, Violeta Ristoiu4, Sabina Zurac^2,3, and Monica Neagu ^1,2,4**

Author Information Open or Close
- ¹Victor Babes National Institute of Pathology, Bucharest, Romania
- ²Colentina Clinical Hospital, Bucharest, Romania
- ³Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
- ⁴Faculty of Biology, University of Bucharest, Romania
*Corresponding author:Emilia Manole, Senior researcher Molecular Biology Laboratory “Victor Babes” National Institute of Pathology, 99-101 Splaiul Independentei, 050096, Bucharest, Romania Research Center, Colentina Clinical Hospital, 19-21 Stefan cel Mare Street, 020125, Bucharest, Romania

Received: April 26, 2018; Published: May 08,2018

DOI: 10.26717/BJSTR.2018.04.001043

Full Text PDF

To view the Full Article Peer-reviewed Article PDF

Abstract

Peripheral nerve injury can be surgically treated, but functional recovery is still unsatisfactory. That is why additional methods that can be applied after surgical repair and which modulate nerve regeneration are sought, this regeneration involving both the morphological recovery of the axon and the myelin sheath, but also the functional, physiological recovery of the peripheral nerve. Thus, in recent years, experimental studies have been undertaken in vivo and in vitro, but also in clinical trials involving electric stimulation, low-level laser therapy and pharmacotherapy. But many of these attempts are not yet standardized and well established, although their effect on the anatomicalfunctional recovery of the peripheral nerve is indisputable. In this review we present a brief overview of the main results obtained in these researches in recent years.

Keywords:Peripheral nerve injury; Electric stimulation; Low-level laser therapy; Pharmacotherapy