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ISSN: 2574 -1241
ISSN: 2574 -1241
Received: April 03, 2018; Published: April 12, 2018
DOI: 10.26717/BJSTR.2018.03.000957
Most of prothrombin initially located within allograft bone matrix is removed or destroyed by deep-freezing, freeze-drying and gamma irradiation. Prothrombin is an inactive precursor to thrombin, a key factor which can promote bone healing. Therefore, we hypothesis that topical administration of autologous prothrombin at sites of bone allografts might be helpful in promoting bone healing after bone allograft transplantation and suggest appropriate amount of venous blood be harvested to concentrate autologous prothrombin before bone allograft transplantation.
Keywords: Prothrombin; Bone Allograft; Bone Healing; Deep-Freezing; Freeze-Drying; Gamma Irradiation
International Association of Landscape Archaeology, Czech Glass Society, Czech Republic
Department of Chemistry, Semenov Institute of Chemical Physics, USSR Academy of Sciences, Moscow, Russia
Pharmaco-kinetics, dynamics and Drug Metabolism, Touro College of Pharmacy, USA
Professor of Nuclear Medicine, Faculty of Medicine and Surgery, University of Milan, Milan, Italy
Associate Professor at Department of Breast and Thyorid Surgey, Chongqing General Hospital, China
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