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*Corresponding author:Quanyi Guo, Institute of Orthopedics of Chinese PLA, Chinese PLA General Hospital, Beijing, China
Received: April 03, 2018; Published: April 12, 2018
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Most of prothrombin initially located within allograft bone matrix is removed or destroyed by deep-freezing, freeze-drying and gamma irradiation. Prothrombin is an inactive precursor to thrombin, a key factor which can promote bone healing. Therefore, we hypothesis that topical administration of autologous prothrombin at sites of bone allografts might be helpful in promoting bone healing after bone allograft transplantation and suggest appropriate amount of venous blood be harvested to concentrate autologous prothrombin before bone allograft transplantation.
Keywords: Prothrombin; Bone Allograft; Bone Healing; Deep-Freezing; Freeze-Drying; Gamma Irradiation