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Topical Administration of Autologous Prothrombin at Sites of Bone Allografts Might be Helpful in Promoting Bone Healing after Bone Allograft Transplantation

Volume 3 - Issue 5

Haibo Lu1,2,3, Shibi Lu3 Wenjing Xu3, Jiang Peng3, Aiyuan Wang3, Quanyi Guo*3, Yong Luo1, Chenyang Nie1 and Sen Li1

  • Author Information Open or Close
    • 1Department of Clinic Medicine, Hospital of People’s Liberation Army Hong Kong Garrison, China
    • 2Department of Orthopaedics, First Affiliated Hospital of Chinese PLA General Hospital, China
    • 3Institute of Orthopedics of Chinese PLA, Chinese PLA General Hospital, China

    *Corresponding author: Quanyi Guo, Institute of Orthopedics of Chinese PLA, Chinese PLA General Hospital, Beijing, China, Tel:8613691133526; Email: lhb2009608@163.com

Received: April 03, 2018;   Published: April 12, 2018

DOI: 10.26717/BJSTR.2018.03.000957

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Abstract

Most of prothrombin initially located within allograft bone matrix is removed or destroyed by deep-freezing, freeze-drying and gamma irradiation. Prothrombin is an inactive precursor to thrombin, a key factor which can promote bone healing. Therefore, we hypothesis that topical administration of autologous prothrombin at sites of bone allografts might be helpful in promoting bone healing after bone allograft transplantation and suggest appropriate amount of venous blood be harvested to concentrate autologous prothrombin before bone allograft transplantation.

Keywords: Prothrombin; Bone Allograft; Bone Healing; Deep-Freezing; Freeze-Drying; Gamma Irradiation

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