+1 (502) 904-2126   One Westbrook Corporate Center, Suite 300, Westchester, IL 60154, USA   Site Map
ISSN: 2574 -1241

Impact Factor : 0.548

  Submit Manuscript

Research ArticleOpen Access

Evaluation of Gelatin-Hybridized Chelate-Setting Calcium Phosphate Cements in Alveolar Bone Defects of Canine Mandible

Volume 3 - Issue 4

Goichi Matsumoto*1,2, Yoshihiko Sugita2, Katsutoshi Kubo2, Waka Yoshida2, Hatsuhiko Maeda2, Mamoru Aizawa3, Shigetaka Shimodaira4 and Yukihiko Kinoshita1,2

  • Author Information Open or Close
    • 1Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, Japan
    • 2Department of Oral Pathology, Aichi-Gakuin University, Japan
    • 3Department of Applied Chemistry, Meiji University, Japan
    • 4Department of Regenerative Medicine, Kanazawa Medical University, Japan

    *Corresponding author: Goichi Matsumoto, Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku-gunn, Ishikawa 920-0293, Japan

Received: March 30, 2018;   Published: April 09, 2018

DOI: 10.26717/BJSTR.2018.03.000931

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF


Aim of this study was to show that modified calcium phosphate cement (CPC) that includes gelatin particles effectively promotes bone regeneration in the canine mandible. The modified CPC is a mixture of hydroxyapatite (HAp) particles, whose surfaces have been modified with inositol hexaphosphate (IP6), and -tricalcium phosphate (-TCP) powder. Mixing powdered gelatin with the HAp surface-modified with IP6 / -TCP cement creates a composite that becomes porous after setting in vivo. For this experiment we produced four experimental mixtures, each with a different concentration of gelatin particles. We created bone defects in the mandibles of beagle dogs, and we injected one of the four experiment materials in each defect. After 6 months, mandibles were removed for micro-CT and histological analyses. These analyses showed that at experimental sites at which the cement had a gelatin particle mixing ratio of 0 mass% and 5 mass%, new bone had formed only at contact boundaries of unresorbed cement. In contrast, at each experimental site at which the gelatin particle mixing ratio of the cement was 10 mass% or 15 mass%, the cement specimen was almost completely resorbed and new bone had formed at the peripheral and internal areas of the original cement mass.

Keywords: Chelate-setting calcium phosphate cement; Inositol hexaphosphate; Gelatin particles; Alveolar bone regeneration; Canine mandible

Abstract| Introduction| Materials and Methods| Results| Discussion| Conclusion| References|