Research ArticleOpen Access

Evaluation of Gelatin-Hybridized Chelate-Setting Calcium Phosphate Cements in Alveolar Bone Defects of Canine Mandible

Volume 3 - Issue 4

**Goichi Matsumoto*^1,2, Yoshihiko Sugita², Katsutoshi Kubo², Waka Yoshida², Hatsuhiko Maeda², Mamoru Aizawa³, Shigetaka Shimodaira⁴ and Yukihiko Kinoshita^1,2**

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- ¹Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, Japan
- ²Department of Oral Pathology, Aichi-Gakuin University, Japan
- ³Department of Applied Chemistry, Meiji University, Japan
- ⁴Department of Regenerative Medicine, Kanazawa Medical University, Japan
*Corresponding author: Goichi Matsumoto, Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku-gunn, Ishikawa 920-0293, Japan

Received: March 30, 2018; Published: April 09, 2018

DOI: 10.26717/BJSTR.2018.03.000931

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Abstract

Aim of this study was to show that modified calcium phosphate cement (CPC) that includes gelatin particles effectively promotes bone regeneration in the canine mandible. The modified CPC is a mixture of hydroxyapatite (HAp) particles, whose surfaces have been modified with inositol hexaphosphate (IP6), and -tricalcium phosphate (-TCP) powder. Mixing powdered gelatin with the HAp surface-modified with IP6 / -TCP cement creates a composite that becomes porous after setting in vivo. For this experiment we produced four experimental mixtures, each with a different concentration of gelatin particles. We created bone defects in the mandibles of beagle dogs, and we injected one of the four experiment materials in each defect. After 6 months, mandibles were removed for micro-CT and histological analyses. These analyses showed that at experimental sites at which the cement had a gelatin particle mixing ratio of 0 mass% and 5 mass%, new bone had formed only at contact boundaries of unresorbed cement. In contrast, at each experimental site at which the gelatin particle mixing ratio of the cement was 10 mass% or 15 mass%, the cement specimen was almost completely resorbed and new bone had formed at the peripheral and internal areas of the original cement mass.

Keywords: Chelate-setting calcium phosphate cement; Inositol hexaphosphate; Gelatin particles; Alveolar bone regeneration; Canine mandible