Aurora A and cancer

Stephanie Le Bras, Arun Prasath Damodaran and Claude Prigent*

Received: February 21, 2018;   Published: April 06, 2018

DOI: 10.26717/BJSTR.2018.03.000922

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Abstract

Aurora-A is a serine-threonine kinase found over expressed in cancers and demonstrated to be an oncogene. Since the kinase regulates cell cycle progression several pharmaceutical companies were involved in the identification of inhibitors to be used in cancer treatments. Many of such inhibitors are now commercially available but none of them succeeded any phase III clinical trials, yet. The concern here is, whether Aurora-A is still a good target or biomarker?

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