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Neonatal Sepsis Past to Present

Volume 3 - Issue 3

Santosh Kumar Kamalakannan*

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- Assistant professor of Neonatology, Saveetha medical college, India
*Corresponding author: Santosh Kumar Kamalakannan, Assistant professor of Neonatology Saveetha medical college, India

Received: March 09, 2018; Published: April 04, 2018

DOI: 10.26717/BJSTR.2018.03.000909

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Abstract

Neonatal sepsis is a clinical syndrome characterized by systemic signs of infection and bacteremia in the neonatal period [1]. Neonatal sepsis is a major cause of mortality and neurodevelopmental impairment among neonates. It contributes to nearly 30 % of neonatal deaths in developing countries [2]. Inherent factors like poorly developed innate immune system, immature skin barrier, mucosal defense mechanisms and blood brain barrier contribute to the increased susceptibility of the neonates to infection .Early recognition and aggressive management plays a pivotal role in saving these neonates. Bacterial infections are the most common cause of septicemia in neonates but fungal and viral infections can occur in the setting of an extreme premature baby and by vertical transmission from the mother.

Abbreviations: EOS: Early Onset Neonatal Sepsis; LOS: Late onset Neonatal Sepsis; NEC: Necrotizing Enterocolitis; RDS: Respiratory Distress Syndrome; UTI: Urinary Tract Infection; GCSF: Granulocyte Colony-Stimulating Factor