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Research ArticleOpen Access

Inhibitory Effect on Lipid Accumulation: Comparison between Two Polymethoxylflavones, Tangeretin and Nobiletin, and One Flavonoid, Hesperetin, in 3T3-L1 Adipocytes

Volume 3 - Issue 1

Jen-Yin Chen1,2, Chin Chen Chu2, Shih-Ying Chen3 and Pin Der Duh4*

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    • 1Department of Senior Citizen Service Management, Chia Nan University of Pharmacy and Science, Taiwan
    • 2Department of Anesthesiology, Chi-Mei Medical Center, Taiwan
    • 3Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Taiwan
    • 4Department of Food Science and Technology, Chia Nan University of Pharmacy and Science, Taiwan

    *Corresponding author: Pin Der Duh, Department of Food Science and Technology, Chia Nan University of Pharmacy and Science, 60 Erh-Jen Road, Section 1, Pao-An, Jen-Te District, Tainan, Taiwan

Received: February 28, 2018;   Published: March 14, 2018

DOI: 10.26717/BJSTR.2018.03.000853

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In this study, two polymethoxylflavones (PMFs), including nobiletin and tangeretin, and one flavonoid, hesperetin with one methoxyl group, were investigated to inhibit lipid accumulation using 3T3-L1 adipocytes. The reducing lipid droplets of the three compounds at 50 μM followed the order nobiletin=tangeretin>hesperetin; the inhibition of triglyceride levels was in the order nobiletin> tangeretin> hesperetin, indicating the numbers of methoxyl groups on the benzene ring play an important role in reducing lipid accumulation. These results imply polymethoxylflavones with high degree of methoxylation are easily permeable to cell membranes and demonstrate more regulating adipogenesis. The findings of this study are useful for designing new antiadipogenic agent and is therefore a potentially lipid lowering compounds based on chemical structure.

Keywords: Nobiletin; Tangeretin; Hesperetin; Polymethoxylflavone; Lipid Accumulation

Abbreviations: PMFs: Polymethoxylflavones; PPARγ: Peroxisome Proliferator-Activated Receptor γ; OROSM: Oil Red O Staining Material

Abstract| Introduction| Materials and Methods| Results and Discussion| Conclusion| Acknowledgement| References|