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Research ArticleOpen Access

Correlation of Hepatitis B Virus Surface Antigen Titer with Hepatitis Delta Virus Replication Level and Histological Activity in Chronic Hepatitis D

Volume 2 - Issue 1

B Pinarbasi Simsek1*, D Onel2, M Gulluoglu3, F Akyuz1, H Issever4, S Badur2, K Demir1, F Besisik1, S Ozdil1, G Boztas1, Z Mungan1 and S Kaymakoglu1

  • Author Information Open or Close
    • 1Departments of Gastroenterohepatology, Istanbul University, Turkey
    • 2Department of Basic Virology and Immunology, Istanbul University, Turkey
    • 3Department of Pathology, Istanbul University, Turkey
    • 4Department of Public Health and Biostatistics, Istanbul University, Turkey

    *Corresponding author: Binnur Pinarbasi Simsek, MD, Millet Cad.34390 Capa, Istanbul, Turkey; Tel: 902129998356; Email:

Received: December 20, 2017;   Published: January 08, 2018

DOI: 10.26717/BJSTR.2018.02.000637

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Purpose: We have analyzed the relationships between quantitative HDVRNA, HBsAg and HBV DNA concentrations and biochemical activity, histological activity index and fibrosis stage in 46 patients with chronic hepatitis D (CHD) and 87 with chronic hepatitis B (CHB), including 33 positive for HBeAg.

Methods: All patients were naïve to treatment. HBsAg concentrations were measured using Abbott Architect kits and HDVRNA by real time PCR.

Results and Conclusions: HBsAg and HDVRNA concentrations were significantly and positively correlated (p=0.043). HDV viremia varied greatly, with HDVRNA titer not correlated with biochemical or histological activity or fibrosis stage. Serum transaminase concentrations and histological findings did not differ between HBVDNA-negative and -positive patients with CHD (p>0.05), and HBsAg concentrations did not differ significantly in HBVDNA-positive and -negative patients (p>0.05). HBsAg levels were significantly higher in HBeAg-positive patients with CHD than in those with HBeAg-negative CHB but were similar in patients with CHD and HBeAg-negative CHB. In CHB patients, there was a positive correlation between serum HBVDNA and HBsAg concentrations (p=0.002). As a result, histological activity and fibrosis stage were significantly higher in CHD than CHB patients, but were not influenced by the levels of HDV and HBV viremia in CHD. HBsAg titers were highest in patients with HBeAg-positive CHB, followed by patients with CHD, and lowest in HBeAg-negative CHB patients.

Keywords: Quantitative hepatitis B surface antigen; quantitative HDV RNA; viral interactions; hepatitis B virus; hepatitis delta virus.

Abstract| Introduction| Materials and Methods| Results| Discussion| References|