+1 (720) 414-3554   600 Third Avenue, 2nd floor, New York - 10016, USA
ISSN: 2574 -1241
Impact Factor 0.548

Research ArticleOpen Access

Effects of the Aqueous Extract of Cnestis Ferruginea on the Histological Structure of Female Rat Ovary and Uterine Horns

Volume 2 - Issue 1

Zougrou N’guessan Ernest, Blahi Adélaïde Nadia, Kouassi Komenan Daouda and Kouakou Koffi

  • Author Information Open or Close
    • Department of Bioscience, University Félix Houphouët-Boigny Abidjan, Côte d’Ivoire, Africa

    *Corresponding author: Zougrou N’guessan Ernest, Department of Bioscience, Biology of Reproduction and Endocrinology Laboratory, University Félix Houphouët-Boigny Abidjan, Abidjan, Côte d’Ivoire, Africa; Email:

Received: December 18, 2017;   Published: January 03, 2018

DOI: 10.26717/BJSTR.2018.02.000625

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF


Cnestis Ferruginea (Connaraceae) is a plant used in the treatment of several affections including “sterility” and increased fertility. This work aims to show the pharmacological effects of the aqueous extract of Cnestis Ferruginea on the ovary and uterine horn of adult female rats. Thirtysix adult female rats were randomized into 2 sets of 18 each and treated for 15 (set I) and 30 days (set II). Each set was then divided equally into three groups. Group 1 (control) was orally administered with distilled water once a day. Group 2 and group 3 were respectively treated with 50 (AECF50) and 100 mg/kg (AECF100) body weight of aqueous extract of C. ferruginea orally once a day. 24 hours after the last doses, the rats of each group are sacrificed. The ovary and uterus of each rat are removed and immediately fixed in 10% formalin for histological study. Cnestis ferruginea induced a significant (p <0.05) increase in the number of corpus luteum after 15 days of treatment with AECF100. After 30 days of treatment, the number of corpus luteum increased significantly (p <0.05) with both doses administered. Both doses also induced significant increases (p <0.05) with the two treatment durations, the number of De Graaf follicles. The number of tertiary follicles increased significantly (p <0.05) with AECF100 after 15 days of treatment. The duration of 30 days allowed recording a significant increase in the number of tertiary follicles with the two doses administered. The other follicles experienced significant increases with AECF100 after 30 days of treatment. For uterine horns, lumen diameters of uterine horns and uterine glands increased significantly (p <0.05) with both doses administered and both durations of treatment. The thickness of the endometrial and the size of the epithelial cells increased significantly (p <0.05) with AECF100 after 15 days of treatment. These latter parameters experienced significant increases with both doses administered at the end of 30 days of treatment. In conclusion, C. ferruginea stimulates folliculogenesis and induces ovulation in the ovary. On the uterine horn, this plant has estrogenic properties.

Keywords: Cnestis Ferruginea; Ovary; Uterine horn; Ovulation; Estrogenic

Abstract| Introduction| Study Areas| Materials and Methods| Vector Density (st. albopicta) and Platynectes beetle Density in the Rubber Plantations| Vector Density (st. Albopicta) and Platynectes Beetle Density in the Rubber Plantations| Results and Discussions| Acknowledgement| References|