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Research ArticleOpen Access

Anti-Microbial Peptides and Their Speculative Role in Periodontitis

Volume 1 - Issue 6

Vinita Ved1 and Gabriela Fernandes2*

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    • 1Dental Intern, YMT Dental College, India
    • 2Department of Oral Biology, School of Dental Medicine, USA

    *Corresponding author: Gabriela Fernandes, Department of Oral Biology, SUNY Buffalo, New York, USA

Received: November 11, 2017;   Published: November 30, 2017

DOI: 10.26717/BJSTR.2017.01.000554

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Abstract

Antimicrobial Peptides (AMPs) are present in the oral cavity in the form of defensins and human cathelicidin LL-37 (from neutrophil granules) and histatins along with pdefensins 1 and 2 (from salivary glands and gingival epithelial cells). The oral micro flora organisms that play an important role in the pathogenesis of periodontal disease are opportunistic pathogens, that are highly proteolytic and this activity is known to contribute to nutrient acquisition, tissue destruction and de-regulation of inflammatory responses. Furthermore, the production of proteases enables oral bacteria to evade killing by antimicrobial peptides, thus contributing to the virulence of such opportunistic pathogens, which could have implications for the use of antimicrobial peptides as therapeutic agents to treat periodontal disease. Hence, this review summarizes the suggestive role of AMPs in periodontal disease.

Key words: Immunity; Anti-Microbial Peptides; Periodontitis

Abbreviations: AMPs: Antimicrobial Peptides, LAP: Lingual Antimicrobial Peptide, HNP: Human Neutrophil Peptide; hBD: Human Beta- Defensins

Abstract| Introduction| Types of Anti-Microbial Peptides involved in Periodontitis| Summary| References|