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Research ArticleOpen Access

A Perceptive of Mass Spectrometry in Clinical Chemistry: Hyphenation for Benefit of Mankind

Volume 1 - Issue 6

Jayshree Ramkumar*

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    • Analytical Chemistry Division, Bhabha Atomic Research Centre, India

    *Corresponding author: Jayshree Ramkumar, Analytical Chemistry Division, Bhabha Atomic Research Centre, Mumbai, India-400085

Received: November 09, 2017;   Published: November 16, 2017

DOI: 10.26717/BJSTR.2017.01.000537

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Abstract

Clinical chemistry is associated with the metabolonomics which is the characterization of metabolome, which is a set of small molecular mass organic compounds found in a given biological medium. Metabolonomics is very important for understanding the toxicity and biomarkers. Mass spectrometry is a very important analytical technique which is used extensive in clinical chemistry. Different types of mass spectrometers are available and thus there is an improvement in the field of clinical chemistry. This overview will touch upon the various aspects of both the clinical chemistry and the mass spectrometry.

Keywords: Clinical chemistry; Mass spectrometry; Ion suppression; Metabolome

Abbreviations: MS: Mass Pectrometry; SPE: Solid-Phase Extraction; NAPQI: N-acetyl-p-benzoquinone Imine; NIH: Institute of Health; HPLC: High-speed high Performance Liquid Chromatography; MALDI: Matrix Assisted Laser Desorption / Ionization; SELDI: Surface Enhanced Laser Desorption Ionization

Abstract| Introduction| Experimental Aspects| Applications in Clinical Chemistry| Challenges in Clinical Mass Spectrometry| Summary| References|