*Corresponding author:
Gottfried L, Division of Plastic Surgery, University of California, San Diego, USA. Home: Wolfsgangstr. 64, D.60322 Frankfurt am Main, GermanyReceived: November 01, 2017; Published: November 09, 2017
DOI: 10.26717/BJSTR.2017.01.000512
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A more serious complication after the injection of all dermal fillers is the late occurrence of foreign body granulomas. The reason must be the retention of a foreign material in the memory of the macrophages, which likely had phagocytosed it years before a granuloma manifests itself as reddish-blue, dense nodules. This sudden granulomatous immune reaction is probably triggered by a sudden systemic bacterial infection which can be recalled by one-third of all granuloma patients. A vigorous removal of small PMMA particles < 20 μm in the only FDAapproved permanent injectable wrinkle filler ArteFill® and deep dermal injections, have decreased the granuloma rate from 0.5%, experienced with earlier-generation products of Artecoll® in Europe, to 0.01% (4 in 42,000 patients) in China when injected in the deep dermis.
Keywords: Injectable microspheres; Injectable microparticles; PMMA; Foreign body granuloma; Dermal filler
Abbreviations: GERD: Gastro-Esophageal Reflux; SUI: Stress Urinary Incontinence; IDD: Degenerative Disc Disease; SEM: Scanning Electron Microscopy
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