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Review ArticleOpen Access

Proteomics - The Future of Periodontal Diagnostics

Volume 1 - Issue 5

Nisha KJ1* and Annie Kitty George2

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    • 1Department of Periodontics, Vydehi Institute of Dental Sciences and Research Centre, India
    • 2Department of Periodontics, Pushpagiri College of Dental Sciences, India

    *Corresponding author: Nisha KJ, Department of Periodontics, Vydehi Institute of Dental Sciences and Research Centre, EPIP Zone, Whitefield, Bangalore, Karnataka, India

Received: October 10, 2017;   Published: October 17, 2017

DOI: 10.26717/BJSTR.2017.01.000447

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Recent advances of proteomic meth¬odologies have opened new opportunities to obtain relevant information on normal and abnormal processes occurring in the human body. Identifying unique patterns of protein expression, or biomarkers, associated with specific diseases is one of the most promising areas of clinical proteomics. Advances in proteomic technologies have enabled comprehensive profiling of protein expression in cells, tissue, and body fluids. The use of proteins as biomarkers for periodontal disease has been the focus of researchers over the last few years. Unfortunately, many single protein biomarkers have proven to be unreliable. Developing new diagnostic tests that can simultaneously analyze the expression of multiple proteins may enable early detection, targeted preventive measures and individualized therapeutic intervention of periodontal diseases. This review discusses the main proteomic techniques and their potential applications in the field of periodontal diagnostics.

Keywords: Proteomics; Biological Markers; Periodontal Diseases; Diagnosis; Gingival Crevicular Fluid; Saliva

Abbreviations: FFF: Field Flow Fractionation; MS: Mass Spectrometry; MALDI-TOF-MS: Matrix-Assisted Laser Desorption/Ionization-Time of Flight Tandem Mass Spectrometry; LC-ESI-MS: Liquid Chromatography-electro Spray Ionization Tandem Mass Spectrometry; SELDI-TOF MS: Surface-Enhanced Laser Desorption/Ionization Time of Flight Mass Spectrometry; Tandem MS: Tandem Mass Spectrometry; IPI: International Protein Index.

Abstract| Introduction| Proteome and Proteomics| Proteomic Tools| Mass Spectrometry| How proteomics applies to medicine and dentistry?| Periodontal Diagnosis - Current State| Where does the future of periodontal diagnosis lie?| Proteomic Biomarkers in Periodontal Disease| Conclusion| References|