Research ArticleOpen Access

CRISPR Technology Challenge Facing the Numerical Integrity of Whole Human Genome DNA

Volume 1 - Issue 4

Jean-claude Perez*

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- Department of Maths and Computer Science, Retired interdisciplinary researcher (IBM), France
*Corresponding author: Jean-claude Perez, Maths and Computer Science Retired interdisciplinary researcher (IBM), 7 avenue de terre-rouge F33127 Martignas, Bordeaux metropole, France

Received: August 05, 2017; Published: September 01, 2017

DOI: 10.26717/BJSTR.2017.01.000321

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Abstract

Background: Global analysis of 3 human genomes of increasing levels of evolution (Neanderthal /Sapiens Build34 / Sapiens hg38) reveals 2 levels of numerical constraints controlling, structuring and optimizing these genome’s DNA sequences. A global constraint - called “HGO” for “Human Genome Optimum” - optimizes the genome at its global scale. The same operator applied to each of the 24 individual chromosomes reveals a hierarchical structure of these 24 chromosomes.

Results: Then analysing the single strand DNA CG / TA proportions at whole chromosomes and genome scale reveals strong fine-tuned numerical ratios evidencing the “closure” nature (Varela’s autopoiesis theory) of whole human genome.

Keywords: Human genome; CRISPR; Biomathematics; Evolution; Autopoiesis