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Review ArticleOpen Access

Pinning Down HELLP: A Review

Hafizur Rahman*

DOI: 10.26717/BJSTR.2017.01.000267

  • Author Information Open or Close
    • Institutional affiliations of author, Professor of Obstetrics and Gynecology, Sikkim Manipal Institute of Medical Sciences, India
    • Corresponding author: Hafizur Rahman, Professor of Obstetrics & Gynecology, Sikkim Manipal Institute of Medical Sciences, 5th Mile, Tadong, Gangtok, Sikkim-737102, India

Received: August 04, 2017;   Published: August 10, 2017

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Abstract

Preeclampsia and HELLP syndrome, both disorders unique to pregnancy, remain a major cause of maternal and neonatal mortality and morbidity worldwide. It is the most common medical disorder complicating pregnancy. In both of these disorders, the liver is a major target with often devastating consequences. The pathogenesis of hepatic damage in cases of severe preeclampsia and HELLP syndrome is not well understood. Diagnosis of HELLP syndrome is heavily relied upon laboratory investigation. In the management, first priority is to assess and stabilize the maternal condition, particularly coagulation abnormalities followed by evaluation of fetal well‑being and finally, a decision must be made as to whether or not immediate delivery is indicated. Women with a prior history of HELLP syndrome carry an increased risk of at least 20% (range 16%-52%) risk of recurrence of some form of hypertension, so future pregnancy counseling and follow up is essential.

|Abstract| |Introduction| |Pathogenesis| |Clinical Presentations| |Diagnosis and Classification| |Maternal and perinatal morbidity and mortality| |Management| |Patient Counseling: Future Pregnancy| |References| ss