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Opinion Open Access

Resveratrol Play as Anti-Heat Stressor Volume 14 - Issue 3

He Yujia1, Hu Ruizhi2, He Shaoping2 and Liu Lei*1

  • 1College of veterinary science Hunan Agricultural University, 410128, Changsha, Hunan, China
  • 2College of animal science and technology, HunanAgricultuapral University, 410128,Changsha, Hunan,China

Received: January 21, 2019;   Published: February 13, 2019

*Corresponding author: Liu Lei, College of Veterinary science, China

DOI: 10.26717/BJSTR.2019.14.002565

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Opinion

A natural botanical polyphenolic compound, resveratrol (3,5,4’-trihydroxy-trans- stilbene) was reported to have anti-oxidation, anti-tumor, anti-inflammatory, neuro-protection and cardiovascular protection effects [1] Numerous studies have shown that resveratrol effectively eliminated reactive oxygen species (ROS), reduced DNA fragmentation, and enhanced the regulatory effects on growth factors and anti-inflammatory cytokines [1]. Resveratrol was considered to be important bioactive compound in monomers, and it has shown strong antioxidant capacity including scavenging free oxygen and lipid radicals [2]. Resveratrol is able to inhibit the formation of glutathione disulfide and keep glutathione in a reduced state, thereby inhibiting free radicals [3]. It has also been shown that resveratrol and its derivatives have activities of antimicrobial (bacterial), and anti-proliferation of cancer cells [4]. In recent study, resveratrol was shown to protect DNA damage against oxidative damage [5].

It has been reported that some plant polyphenols can also be used as anti-stress additives of livestock and poultry to alleviate tissue damage caused by heat stress [6,7]. Heat stress causes an imbalance in physiological status, a general reduction of the antioxidant system, and a reduction in the immunological function of chickens [8]. The research team leading by Dr. Jianhua He conducted a series of trial with broiler chicken to verify the anti-heat stress effect of resveratrol [1,9,10]. The resveratrol (≥98% purity) they used to be extracted from Polygonum cuspidatum at Hunan Engineering and Technology Center for Natural Products. He [9] reported that Resveratrol supplementation improved average daily gain (p = 0.001) and decreased (p < 0.05) rectal temperature from d 3 when compared with heat-stressed (maintain room temperature at 34℃ for 8h from 9:00 to 17:00) birds fed diet without resveratrol. In addition, supplementation with resveratrol at 350 or 500 mg/kg lowered (p < 0.05) the contents of corticosterone, adrenocorticotropic hormone (which are highly related to heat stress); it also decreased the content of triglycerides, uric acid, malonaldehyde, and activities of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase, increased (p < 0.05) the levels of triiodothyronine, the ratio of triiodothyronine to thyroxine, total protein, glutathione, and activities of alkaline phosphatase, total superoxide dismutase, catalase, and glutathione peroxidase, the above results suggested that dietary resveratrol supplementation could improve the growth performance by positively regulating serum metabolic parameters and alleviating tissue oxidant damage of broilers under heat stress. The results provided by Liu [10] also showed that dietary supplemented with resveratrol improved growth performance, feed intake and body weight gain of blackboned chickens during heat stress period, while feed conversion ratio was decreased. And it reduced oxidative stress in heat-stressed black-boned chickens by increasing serum growth hormone concentrations and modulating the genes expression of heat shock protein in organs of the immune system. She also found that dietary supplementation with 400mg/kg of resveratrol improved the villus morphology, increased the numbers of goblet cells and lymphocytes, attenuated the mRNA overexpression of HSP70, HSP90 and NF-κB on the 6th, 10th and 15th days of heat stress (maintain room temperature at 34℃ for 8h from 9:00 to 17:00)(P <0.05), activated the expression of EGF (P <0.05) in the jejunal mucosa.

Resveratrol reduced protein expression of HSP70, HSP90 and NF-κB in the jejunal villus after 15-days heat stress, increased EGF expression from the lamina propria toward the epithelial cells of the villus. These results suggest that dietary resveratrol offers a potential nutritional strategy to improve intestinal morphology and alleviate jejunum mucosa injuries by modulating the mRNA and protein expression of HSPs, epithelial growth factor and transcription factor in black-boned chickens subjected to circular heat stress. Liu [1] found that Resveratrol attenuated the heat stress-induced overexpression of Hsp27, Hsp70, and Hsp90 mRNA in the bursa of Fabricius and spleen and increased the low expression of Hsp27 and Hsp90 mRNA in thymus upon heat stress. Preliminary studies also have indicated some benefits of resveratrol supplementation to alleviate negative effect of heat stress, and increased SOD, GSHPx and CAT enzyme activities in mice [11], quail [7] during heat stress exposure. Das [11] also observed that resveratrol is able to resist the body organ dysfunction induced by heat stress. Sahin [7] reported that resveratrol can inhibit the high-levels of HSP70/90, NF-κB proteins in quail liver during heat stress. In conclusion, dietary supplementation of resveratrol could alleviate the heat-stress effect of broiler by reduced oxidative stress and its recovery effect of intestinal damage caused by heat stress. It was suggested that eat resveratrol containing herbs or food may play benefit effect for Human in tropic area.

References

  1. Lili Liu, Chenxing Fu, Mingli Yan, Hongbing Xie, Si Li, et al. (2016) Resveratrol modulates intestinal morphology and HSP70/90, NF-κB and EGF expression in the jejunal mucosa of black-boned chickens on exposure to circular heat stress. Food Funct 7(3): 1329-1338.
  2. Krishna PLB, WK Jerome, MP John (2001) Biological effects of resveratrol. Antioxid Redox Signal 3(6): 1041-1064.
  3. Hung LM, Chen JK, Huang SS, Lee RS, Su MJ (2000) Cardioprotective effect of resveratrol, a nature antioxidant derived from grapes. Cardiovase Res 47(3): 549-555.
  4. Katalinić V, Možina SS, Skroza D, Generalić I, Abramovič H, et al. (2010) Polyphenolic profile,antioxidant properties and antimicrobial activity of grape skin extracts of 14 Vitis vinifera varieties grown in Dalmatia(Croatia). Food Chemistry 119(2): 715-723.
  5. Yan Y, JY Yang, YH Mou, LH Wang, YN Zhou, et al. (2012) Differences in the activities of resveratrol and ascorbic acid in protection of ethanolinduced oxidative DNA damage in human peripheral lymphocytes. Food Chem Toxicol 50(2): 168-174.
  6. Aengwanich W, M Suttajit (2010) Effect of polyphenols extracted from Tamarind (Tamarindus indica L.) seed coat on physiological changes, heterophil/lymphocyte ratio, oxidative stress and body weight of broilers (Gallus domesticus) under chronic heat stress. Anim Sci 81(2): 264-270.
  7. Sahin K, C Orhan, F Akdemir, M Tuzcu, C Iben, et al. (2011) Resveratrol protects quail hepatocytes against heat stress:modulation of the Nrf2 transcription factor and heat shock proteins. J Anim Physiol Anim Nutr 96(1): 66-74.
  8. Panda AK, SV Ramarao, MV Raju, RN Chatterjee (2008) Effect of dietary supplementation with vitamins E and C on production performance, immune responses and antioxidant status of White Leghorn layers under tropical summer conditions. Br Poult Sci 49(5): 592-599.
  9. He Shaoping, Si Li, Muhammed Adebayo Arowolo, Qifang Yu, Fu Chen, et al. (2019) Effect of resveratrol on growth performance, rectal temperature and serum parameters of yellow-feather broilers under heat stress. Anim Sci J.
  10. Liu LL, JH He, HB Xie, YS Yang, JC Li, et al. (2014) Resveratrol induces antioxidant and heat shock protein mRNA expression in response to heat stress in black-boned chickens. Poult Sci 93(1): 54-62.
  11. Das A (2011) Heat stress-induced hepatotoxicity and its prevention by resveratrol in rats. Toxicol Mech Methods 21(5): 393-399.