Zachary S Zeigler*
Received: August 15, 2018; Published: August 20, 2018
*Corresponding author: Zachary S Zeigler, College of Science, Engineering, and Technology, Grand Canyon University, Phoenix, USA
Obesity is a global problem, impacting an estimated 300 million people worldwide . Its prevalence is increasing in both developed and developing countries throughout the world. In the United States, the prevalence of obesity is greater than it has ever been, with striking increases observed during the past 2 decades . The economic costs of obesity are astounding. It is estimated that by the year 2030, 48-66 billion dollars/year will be spent on obesity related medical costs . With the increased obesity prevalence and the accompanied disease risk associated with obesity , both healthcare provider and patient have a strong desire to lose weight. A 2003-2008 national survey of 16,720 Americans found that 73% of women and 55% of men have a desire to lose weight while approximately 50% of women and 30% of men actively engaged in weight loss efforts within the preceding year . Disappointing, results from weight loss attempts are dismal at best. It was noted obesity researcher Albert Stunkard who stated, "most persons will not stay in treatment for obesity. Of those who stay in treatment, most will not lose weight, and of those who do lose weight, most will regain it". Stunkard's opinion has been verified through published studies that show successful treatment of obesity remains the exception rather than the rule. One of the more positive studies show that a mere 20% of obese persons who attempt to lose weight achieve and maintain clinically meaningful weight loss . Attrition rates in obesity trials range from 10-80% . In strictly controlled single-center randomized studies the attrition rate exceeds 40% at 12 months regardless of the type of dietary program .
Clinically, a 10% weight loss goal is recommended because a significant decrease in obesity-related mortality is seen . Yet the majority of overweight/obese persons seeking weight loss consider 10% unsatisfactory . It has been reported that women participating in weight-loss programs have an unrealistic goal weight as 32% lower than current body . An analysis published in 2007 assessed weight outcomes in research studies with a minimum follow-up of 12 months to determine treatment effectiveness for weight loss and maintenance. Roughly 26,000 subjects spanning 80 studies were followed, and of that 26,000, 31% decided to quit their respective study. Of those who did complete the study it was found that regardless of method of weight loss, average weight loss by 48 months was a mere 3% to 4% of starting body weight.
When unrealistic goals are set and unmet, something happens to the psyche that renders a feeling of defeat. Research on goal setting observes that when goals are not reached or when progress toward them are unsatisfactory, people have negative emotions , impaired task performance , and abandon their attempt to achieve their goal . Unrealistic weight loss goals seem to support this as data show that a higher initial weight loss expectation predicts drop-out from the perspective weight loss program [14,15]. Additionally, small retrospective studies have found that having unrealistic weight loss goals may contribute to poor weight maintenance [16-18]. It has also been found that the time to drop-out is progressively shorter in relation to expected BMI loss . It should be noted that the fitness and health community have been trying for the past three decades to reduce obesity rates with no success whatsoever. Do I need to remind all the definition of insanity, doing the same thing over and over again but expecting different results? It is my opinion that focus within the obese population needs to be shifted away from the scale to something more realistically achieved.
Missed in the "you must lose weight, or you will die" conversation is the plethora of data showing the ability to improve health in the absence of weight loss . The DASH diet for example showed significant reductions in blood pressure (-12/5mmHg) in response to a diet intervention while weight was maintained . Furthermore, both aerobic and resistance exercise have been shown to reduce hepatic and visceral fat without weight loss [22,23]. Additionally, lifestyle intervention, independent of weight loss, has shown to favorably impact diabetes risk , improved blood lipid profile , enhanced endothelial function , decreased inflammation , improved mitochondrial function , and improved postprandial metabolism . Using the words of Blair and Le Monte  'there has been an overemphasis on weight loss as a clinical target'. Because achieving a meaningful weight loss is elusive, emphasis should be shifted to health promoting lifestyle factors such as increasing fitness.
The concept of "fat and fit" has been most notably highlighted by Dr. Steve Blair as he has highlighted the importance of measured cardiovascular fitness on all-cause mortality [31,32]. Much of his data has been derived from the prospective Aerobic Center Longitudinal Study that followed > 80,000 people over 35 years. A 2007  paper by Dr. Blair examined the relationship among fitness level, different measures of fatness, and cancer mortality among men. It was found that regardless of BMI category, body fat percentage, or even waist circumference, it was better to be 'fat and fit' than to be normal weight but unfit. A 2010 review paper  assessed 36 studies that addressed the question, "which is a greater health risk, poor cardio-respiratory fitness or obesity" The outcomes that were looked at were mortality and morbidity, cardiovascular disease, and type 2 diabetes. It was found that the risk for all-cause and cardiovascular mortality was lower in individuals with high BMI and good aerobic fitness, compared with those with normal BMI and poor fitness. Other reviews have been conducted and agree that aerobic fitness counteracts the deleterious effects of obesity [35-37].
Observational prospective studies show that one can indeed be "fat and fit" . A physically active lifestyle is associated with reduced CVD risk irrespective of abdominal adiposity. The EPIC- Norfolk study involving more than 10,000 subjects followed for over 10 years found that abdominally obese men and women who reported being active had lower CHD risk compared to inactive persons despite their abdominal obesity . Work by Church and Blair found that among 2300 subjects with diabetes followed for roughly 16 years, poor fitness, not obesity, was associated with reduced survival probability . Moving from sedentary to active activates genes that are involved in many structural, physiological, and metabolic adaptations that make the body more competent to perform physical activity but also provide cardiometabolic protection irrespective of weight loss .
To summarize, when an obese patient is assessed in the clinical setting, almost always advice to lose weight is given. Statistically speaking, the healthcare provider just asked the patient to do something very few can accomplish. On the other hand, even if some weight loss is seen, it is more than likely not enough to be deemed satisfactory to the patient. Thus, feelings of failure set in and eventually total recidivism is seen. In light of this, and when considering that genetics explains anywhere from 25-70% of body mass , maybe we shift the focus away from the scale and onto the behaviors that have been shown to produce positive health outcomes. Other researchers have suggested that focus be shifted to patients favorably changing lifestyle factors without placing a focus on weight loss . Why not simply measure number of minutes engaged in physical activity, or measure fitness levels? These would be easily obtained outcome goals yet are almost never utilized in the clinical setting. The American College of Sports Medicine and the American Medical Association has initiated a global campaign titled Exercise is Medicine . At the center of this campaign if for healthcare practitioners to actually "prescribe" exercise to their patients. It is my opinion that if the focus of obesity interventions where placed on physical activity adherence, not the scale, enhanced adherence rates would be witnessed, and consequentially improved health outcomes would be conferred.