Trifluoroacetic Acid-Promoted Friedel-Crafts Aromatic Alkylation with Benzyl Alcohols

Amy L Ladd and Gordon W Gribble*

Received: December 07, 2018;   Published: December 20, 2018

DOI: 10.26717/BJSTR.2018.12.002509

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Abstract

Following the 1945 report by Newman on the utility of Trifluoroacetic Acid (TFA) as a condensing agent for the acylation of anisole with acetic anhydride [1], TFA has found enormous utility in organic synthesis [1-3]. For example, TFA is useful in protecting group removal, as a solvent for radical and polymer processes, oxidations, reductions, and other reactions [2].

Abbreviations : PFP: Proximal Femoral Plate; AO/ASIF: Association for Osteosynthesis/Association for the Study of Internal Fixation; HHS: Harris Hip Score