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The Association of Carotid Intima-Media Thickness with Endocrine Disrupting Chemicals

Volume 12 - Issue 1

Wei Jie Wang1,2, Chien Yu Lin3,4, Ta Chen Su5,6, Sheng Wen Ko1 and Jui Hsiang Lin*1,7,8

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    • 1Department of Internal Medicine, Taiwan
    • 2Department of Biomedical Engineering, Taiwan
    • 3Department of Internal Medicine, Taiwan
    • 4School of Medicine, Taiwan
    • 5Institute of Occupational Medicine and Industrial Hygiene, Taiwan
    • 6Department of Internal Medicine and Cardiovascular Center, Taiwan
    • 7Graduate Institute of Clinical Medicine, College of Medicine, Taiwan
    • 8Faculty of Medicine, Taiwan
    • *Corresponding author: Jui Hsiang Lin, Division of Nephrology, Taiwan

      Sinwu Branch, Department of Internal Medicine, Taiwan

Received: December 05, 2018;   Published: December 14, 2018

DOI: 10.26717/BJSTR.2018.12.002207

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Endocrine disrupting chemicals (EDCs) involving phthalate metabolites, Bisphenol A, and perfluorooctane sulfate are chemicals that have the capacity to modulate endocrine systems. EDCs may aggravate subclinical atherosclerosis in a population of adolescents and young adults. We review articles including environmental exposure of EDCs and carotid intima-media thickness to infer atherosclerotic potentials of EDCs exposure. Urinary metabolite of mono-2-ethylhexyl phthalate is the major component of phthalate-induced atherogenic pathogenesis. EDCs may aggravate subclinical atherosclerosis in the population of adolescents and young adults. The important circumstantial relationship between EDCs and subclinical atherosclerosis should pay more attention in primary prevention of environmental cardiology.

Keywords :Endocrine Disrupting Chemicals; Carotid Intima-Media Thickness; Atherosclerosis

Abbreviations : EDCs: Endocrine Disrupting Chemicals; DM: Diabetes Mellitus; MBzP: Mono-Benzyl Phthalate; MEHP: Mono-2-Ethylhexyl Phthalate; CIMT: Carotid Intima-Media Thickness; BPA: Bisphenol A; PFOA: Perfluorooctanoic Acid; PFOS: Perfluorooctane Sulfate; PFCs: Perfluorinated Compounds; NHANES: National Health and Nutrition Examination Survey

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