Deducing Immortality

Aprajita*

Received: December 04, 2018;   Published: December 13, 2018

DOI: 10.26717/BJSTR.2018.12.002203

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Abstract

Stem cells can express telomerase while telomerase activity is widely suppressed in somatic cell, resulting in senescence because of telomere shortening during replication. The level of expression of telomerase expressing gene (hTERT gene) is lower in adult stem cell whereas high in embryonic and cancer stem cell. Till now the level of hTERT expression is not even studied in pluripotent stem cell, as c-Myc gene plays a major role in up regulating hTERT. This study is about the interconnection between c-Myc being a stem cell pluripotency factor and an up regulator for telomerase.

Keywords :Chromosome; Transcription; Clustal Omega; Reprogrammed Gene

Abbreviations : hTERT: Telomerase Reverse Transcriptase in Humans; RNA: Ribonucleic Acid; IPSC: Induced Pluripotent Stem Cells