Malignant Transformation of Exophytic Sinonasal
Papilloma: Case Report

István Magyarosi; J Cifra; I Takács; K Somogyvári; P Móricz

doi:10.26717/BJSTR.2018.12.002192

Case ReportOpen Access

Malignant Transformation of Exophytic Sinonasal Papilloma: Case Report

Volume 12 - Issue 1

**István Magyarosi*¹, J Cifra², I Takács³, K Somogyvári⁴ and P Móricz¹**

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- ¹Department of Otorhinolaryngology, János Balassa County Hospital, Hungary
- ²Department of Pathology, János Balassa County Hospital, Szekszárd, Hungary
- ³University of Pécs Medical School, Department of Surgical Research and Techniques, Hungary
- ⁴University of Pécs Medical School, Department of Otorhinolaryngology and Head- and Neck Surgery

Received: December 04, 2018; Published: December 12, 2018

DOI: 10.26717/BJSTR.2018.12.002192

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Abstract

Malignant transformation of exophytic sinonasal papilloma (SP) is exceptionally rare. The authors present a case of a 48 years old woman who presented to hospital with unilateral nasal obstruction, a tissue mass in the right nasal entrance. After CT scans of the paranasal sinuses endoscopic surgery was carried out, and the lesion was removed. The histological examination discovered an exophytic SP with a part of squamosus cell carcinoma. The patient underwent radiotherapy. After that the thickened mucosa from the right sinus maxillaries was removed. Histological examination revealed SP fragments in the polypoid mucosa without any sign of malignancy. To date we have found no sign of recurrent papilloma or carcinoma. The pathogenesis of papillomas is not clear. In one third of sinonasal papillomas HPV-6 and 11 are present. In our patient no HPV DNA was identified in the removed tissues. The carcinoma and the dysplastic area was p16 positive, while the exophytic SP epithelium was negative.