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Review ArticleOpen Access

Rapid Progress in Diagnosis of ANCA-associated Vasculitis

Volume 11 - Issue 3

Mahmoud Al-Azab1, Abdou Ellabban2, Salah Adlat3, Marwan AL-Moiliqy1, Mohammed Abdo1, Haithm Mousa1, Yaser Jamalat1, Abdulla Shopit1, Eskandar Qaed1 and Bing Wang*1

  • Author Information Open or Close
    • 1Department of Immunology, Dalian Medical University, Dalian, Liaoning, China
    • 2Department of Rheumatology, Hargeisa International Hospital, Somalia
    • 3Key Laboratory of Molecular Epigenetics of MOE, School of Life Science, Northeast Normal University, 130024 Changchun, Jilin Province, China
    • *Corresponding author: Bing Wang, Department of Immunology, College of Basic Medical Science, Dalian Medical University, Lvshun South Road, Dalian116044, China

Received: November 22, 2018;   Published: November 29, 2018

DOI: 10.26717/BJSTR.2018.11.002119

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Diagnosis of ANCA associated vasculitides (AAVs) represents a big burden in the medical field because of clinical features diversity. Wegener’s granulomatosis or granulomatosis with polyangiitis (GPA), Churg-Strauss syndrome or eosinophilic granulomatosis with polyangiitis (EGPA), and microscopic polyangiitis (MPA) are the main small-vessel vasculitis. GPA presents in the head and neck, and the Sinonasal cavity is among the most common areas affected. EPGA is occurring within patients with a history of asthma, whereas MPA is known by poor immune complexes markers in histopathology section. In addition, kidney and lung commonly involved in patients with MPA, this may sequentially involve the nervous and musculoskeletal systems. Moreover, skin, heart, eyes, and intestine can be involved. Due to of those varieties and overlapping in signs and symptoms the proper diagnosis is still an urgent need in AAVs management. Although detection of ANCA autoantibodies and histopathology reporting still essential tools for AAVs investigation, it has been reported that they are not enough for definitive diagnosis.

Keywords : Diagnosis; Anti-neutrophil cytoplasmic autoantibody (ANCA); ANCA-Associated Vasculitis (AAVs); granulomatosis with polyangiitis (GPA); Eosinophilic granulomatosis with polyangiitis (EGPA); microscopic polyangiitis (MPA)

Introduction| Conclusion Remarks| Acknowledgement| References|