In Vitro Characterization of Mems Based Piezoelctrically Actuated Drug Delivery Device for Biomedical Applications

Joyline Dsa*, Vineel Kaipu, Manish Goswami and BR Singh

Received: November 16, 2018;   Published: November 26, 2018

DOI: 10.26717/BJSTR.2018.11.002093

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Abstract

Implantable devices that detect and treat diseases without any intervention required from the patient are expected to be the trend of the future. This paper presents a peizo electrically controlled MEMS drug delivery device for on-demand release of defined quantities of drug in a sustained and controlled manner. A drug-loaded polymer based micro reservoir (600μm ×550μm) is sealed by a Polydimethylsiloxane (PDMS) membrane placed over the drug reservoir on which the piezoelectric material is deposited. On application of voltage across this piezoelectric material, the membrane deflects allowing the fluid to fill into the chamber that will mix with the drug and due to concentration variation; the drug would come off the reservoir or vice versa. A 0.3μm-thick PZT material is deposited on 20μm PDMS membrane. Discharge of the drug solution and the release rates were controlled by an external electric field. Characterization of the devices was implemented in-vitro using the colored water solution. The reservoir was capable of delivering 20μl drug on application of 10V.

Keywords : Polydimethylsiloxan; Drug Delivery; PZT Material