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Plantibodies: A New Approach for Immunomodulation in Human Health

Volume 11 - Issue 2

Himani Punia1 and Anurag Malik*2

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    • 1Department of Chemistry & Biochemistry, India
    • 2Department of Seed Science & Technology, India
    • *Corresponding author: Anurag Malik, Department of Seed Science & Technology, India

Received: November 04, 2018;   Published: November 19, 2018

DOI: 10.26717/BJSTR.2018.11.002061

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Antibodies or immunoglobulins are the vital component of adaptive immune system in mammals. These are mainly present in the body fluid and constitute an assembly of glycoproteins released by B-cells. B-cells constitute the humoral type of adaptive immune system. They are highly specific their mode of action. First they recognize their target specifically, binds to the antigen/toxin of pathogen and produce and elicit the immune response. These features permit immunoglobulins to be employed in diverse range of applications such as diagnosis, prevention and treatment [1]. Production of defective antibody response results in increased vulnerability to pyogenic infections due to impairment in B-cell function, e.g. in hyper-IgM syndrome as a result of improper signaling between B and T cells and in X-linked agammaglobulinemia. To overcome these defects, constant region of a human immunoglobulin is modified by transgenic approach to create recombinant antibody [2]. With this advancement, a new expectation of a reliable, inexpensive cure for diseases like, diabetes and cancer was awakening; but the major drawback was its cost ineffectiveness.

Introduction| Benefits of Using Plants as Host For Mammalian Antibody Production| Uses of Plantibodies in Medicine| Conclusion| References|