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Research ArticleOpen Access

Predictors of Nerve Conduction Study Parameters among Type 2 Diabetic Patients: A Cross -Sectional Study

Volume 11 - Issue 2

Wakode SL*1, Thakre AE1, Hulke SM1 and Wakode NS2

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    • 1Associate Professor, Department of Physiology, AIIMS BHOPAL, India
    • 2Associate Professor, Department of Anatomy Government Medical College Vidisha, India
    • *Corresponding author: Santosh Laxman Wakode, Associate Professor, Department of Physiology, AIIMS Bhopal, India

Received: November 08, 2018;   Published: November 19, 2018

DOI: 10.26717/BJSTR.2018.11.002060

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The prevalence of diabetes is rapidly rising all over the globe and India is becoming the world capital for diabetic patients. Persistent hyperglycemia leads to micro vascular complications like diabetic peripheral neuropathy (DPN) which contributes to significant morbidity in the society. Recent research reported that NCS could be used for the early detection & prediction of DPN.The present cross –sectional study was carried to explore relations of NCS parameters and different variables among type 2 diabetic patients. Data of total 50 (male & female) type 2 diabetic patients on regular oral hypoglycemic agents with disease duration not less than two years was collected and analyzed to find out correlations between NCS parameters like motor & sensory conduction velocity (MNCV, SNCV), motor and sensory action potential amplitude (CMAP, SNAP) with duration of disease , fasting & post meal blood glucose (FBG, PMBG) & body mass index (BMI). Significant negative correlation (p<0.05) was seen between the disease duration and all the NCS parameters studied, between the fasting blood glucose (mean value 137.88± 34.14 mg/dl) and MNCV and SNAP, between post meal blood glucose (mean value 213.90 ± 67.72 mg/dl) and MNCV, SNCV, SNAP and also between BMI (mean value 28.94±4.27 kg/m2 ) and MNCV and SNCV. The negative correlations of nerve conduction parameters with different variables indicates subclinical nerve dysfunction, therefore thorough neurological examination along with NCS should be carried out early in the course of disease.

Abbreviations : DPN: Diabetic Peripheral Neuropathy, MNCV: Motor Conduction Velocity, SNCV: Sensory Conduction Velocity, FBG: Fasting Blood Glucose, PMBG: Post Meal Blood Glucose, BMI: Body Mass Index, MNAP and SNAP: Motor and Sensory Action Potential Amplitude, NCS: Nerve Conduction Studies, DPN: Diabetic Polyneuropathy, DM: Diabetes Mellitus

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