The Efficacy of Intra-Muscular Botulinum Toxin A (Btx-A) Injections on Spasticity Reduction in Spastic Cerebral Palsy

Zaid Al Dahamsheh*, Kareem Al Rashdan, Awni Al Hadid, Mohammed Al Bakheet and Emad Al Soub

Received: October 08, 2018;   Published: October 23, 2018

DOI: 10.26717/BJSTR.2018.10.001922

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Abstract

Introduction: Cerebral palsy (CP) is known as a c

Study Objectives: the main objective of the present study is to investigate the impact of BTX-A injection on the spasticity scores of children with CP.

Methods and Subjects: A prospective study design was conducted from January 2017 to June 2018 at Royal Rehabilitation Center. A total of 128 children with CP were included. Children with were treated with BTX-A and followed for 3 and 6 months. At basal level, demographical and clinical data were recorded. Data included age, gender, and spasticity scores. Spasticity scores were determined using Modified Ashworth Scale pre and post injections.

Study Results: The age mean was 8.73±5.70 years. The score of spasticity at basal level was 3.34±0.67, and then it was decreased further after three months follow up and reached 1.27±0.99. The spasticity score was further increased to the level of 3.07±0.86 after 6 months follow up. There was a significant impact of using single injection of BTX-A on lowering the spasticity score levels after 3 months and 6 months follow up (p< 0.001). There were also significant differences in the mean of scores at 3 and 6 months follow up (p< 0.001). At basal level, males have significantly increased levels spasticity scores compared with females (p=0.002). At 3 and 6 months follow up, no significant differences were attributed to gender (p>0.05).

Conclusion:The study findings showed that single doses of ABT-X has therapeutic effects in decreasing the levels of spasticity scores.

Keywords: Cerebral Palsy; Spasticity; Spasticity Scores; ABTX-A; Modified Ashworth Scale

Abstract | Introduction| Methods and Subjects| Results| Discussion| Conclusion| References|