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Prospects of Perineural Administration of Autologous Mesenchymal Stem Cells of Adipose Tissue in Patients with Cerebral Infarction

Volume 10 - Issue 1

Shanko Yuri1, Navitskaya Valeria1, Zamaro Alexandra2, Krivenko Svetlana3, Zafranskaya Marina4, Pashkevich Svetlana2, Koulchitsky Stanislav5, Takalchik Stukach Yulya2, Denisov Andrew2 and Kulchitsky Vladimir*2

  • Author Information Open or Close
    • 1 Republican Scientific and Practical Center of Neurology and Neurosurgery, Minsk, Belarus
    • 2 Institute of Physiology, National Academy of Sciences, Minsk, Belarus
    • 3 Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology, Minsk, Belarus
    • 4 Belarusian Medical Academy of Post-Graduate Education, Minsk, Belarus
    • 5 Liege University, Liege, Belgium
    • *Corresponding author: Kulchitsky Vladimir, Institute of Physiology, National Academy of Sciences, Minsk, Belarus, Europe

Received:October 08, 2018;   Published: October 11, 2018

DOI: 10.26717/BJSTR.2018.10.001884

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Background: Frustrating statistics of therapy of patients with cerebral infarctions is well known. Longstanding deficiency of somatic and visceral functions is one of the negative consequences of existing therapy. Such state is developed due to persistent structural and functional lack of central control of various body activities by brain neural networks. Finally, most of the patients have severe invalidities even in distant period after performed treatment. Therefore, development and implementation of technologies that will allow activating reparative processes in brain after cerebral infarction is one of prospective tasks.

Aims: development and implementation of new technique of cerebral infarctions treatment using autologous mesenchymal stem cells (MSC) of adipose tissue.

Methods: Authors developed unique technique aimed at formation of conditions for natural migration of stem cells (SC) to the area of cerebral infarction after their endoscopic administration into nasal submucosa

Results: Autologous mesenchymal stem cells (MSC) of 25 patients naturally migrated to the area of cerebral infarction after their administration into nasal submucosa. The process of MSC differentiation into neuron-like elements after penetration to cranial cavity was previously shown in experiments. Patients with primary cerebral infarctions (n=12) and secondary ones (n=8) showed statistically significant improvement of physiological functions control in 6 months after course therapy with SC assessed by National Institutes of Health Stroke Scale (NIHSS) and Glasgow Coma Scale (GCS), respectively. Administration of allogeneic SC to patients with cerebral infarctions (n=5) was ineffective.

Discussion and Conclusion Combination of standard therapy of cerebral infarctions with endoscopic perineural implantation of autologous MSC of adipose tissue is accompanied with activation of reparative processes leading to recovery of neurologic functions.

Keywords : Cerebral infarction, Mesenchymal stem cells, Perineural implantation, Patient, Reparative process

Abbreviations : GCS: Glasgow Coma Scale; MSC: Mesenchymal Stem Cells; NIHSS: National Institutes of Health Stroke Scale; SC: Stem Cells

Abstract | Introduction| Materials and Methods| Results| Discussion and Conclusion| Acknowledgement| References|