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Role of Genetic Factors in the Course of Echinococcosis Disease

Volume 9 - Issue 5

Lukmanova GI1*, Nartailakov MA2 and Lukmanov MI3

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    • 1 Professor of the Department of Biology, Bashkir state medical University, Russia
    • 2 Professor, Head of the Department of General Surgery, Bashkir state medical University, Russia
    • 3Assistant of the Department of General surgery, Bashkir state medical university, Russia

      • *Corresponding author: Lukmanova GI, Professor of the Department of Biology of Bashkir state medical University, 450005, Ufa, Lenin 3, Russia

Received:September 28, 2018;   Published: October 11, 2018

DOI: 10.26717/BJSTR.2018.09.001879

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Abstract

For several years, we conducted a study of the role of genetic factors in the pathogenesis of echinococcosis among residents of the Republic of Bashkortostan. The associations of polymorphic allele’s genes of cytochrome P-450 (CYP1A1, CYP1A2), glutathione-S-transferases (GSTM, GSTT), cytokines (TNFA), the specificities of Human Leukocyte Antigens (HLA-A, B, DRB1, DQB1) and blood groups AB0 with echinococcosis have been studied. Based on the analysis of the results, it was shown that genetic factors play a role in the invasion of Echinococcus granulosus with genotype G1 (common, domestic sheep).

Keywords : Genetic Factors; Echinococcosis; Albendazole; Cytochrome P450; Polymorphic; Sulfoxide; Enzymes; Catalytic; Patients; Helminthiasis

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