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The Roles for Fusobacterium Nucleatum in Human Colorectal Carcinogenesis

Volume 9 - Issue 2

Xiang li*1, Jiepeng Huang1, Penglin Zhu2, Yifan Wu1, Lingfeng Lou*1 and Yongliang You1

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    • 1Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical University, China
    • 2Renji College, Wenzhou Medical University, China

    *Corresponding author: Yongliang Lou and Xiang Li, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical University, Qiuzhen Road, Chashan, Wenzhou, Zhejiang 325035, PR China

Received: September 17, 2018;   Published: September 25, 2018

DOI: 10.26717/BJSTR.2018.09.001780

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Abstract

Colorectal cancer (CRC) is one of the most common malignant tumors. There are many risk factors involved in CRC. According to recent findings, Fusobacterium nucleatum (F. nucleaum) are closely related to the progression of CRC. Studies have found that F. nucleaum may contribute to the development and prognosis of inflammation and CRC. The factors of the pathogenicity of F. nucleaum include its adhesion, its metabolite butyric acid, the cell factor of the host, and so on. Underlying mechanisms of F. nucleatum in CRC remain to be established.

Keywords: Colorectal cancer (CRC); Fusobacterium nucleatum; Pathogenicity; Adhesion; Butyric acid

Abstract | Introduction | Conclusion | Acknowledgement | References |