*Corresponding author:Bihorac Ajna, MSc, University of Belgrade, Faculty of Biology, Department of Molecular Biology and Physiology, Serbia
Received: September 13, 2018; Published: September 19, 2018
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Cancer is a disease extremely difficult to defeat. Besides tumor cells, the microenvironment is influencing progress and metastasis. Recently, it has been discovered that macrophages may promote progress of the tumors. Those tumors associated macrophages (TAMs) are still not completely defined and their role not fully described. If the phenotype of the macrophages can influence the outcome of the tumor disease, the focus should be on TAMs and their potential in development of personalized therapy in fighting metastatic tumors.
Abbreviations: TAMs: Tumor Associated Macrophages; CSF-1: Colony Stimulating Factor 1; M-CSF: Macrophage Colony Stimulating Factor; ECM: Extracellular Matrix; EGF: Epidermal Growth Factor; TNF: Tumor Necrosis Factor; VEGF: Vascular Endothelial Growth Factor; MMP: Matrix Metalloproteinases; TGFβ: Transforming Growth Factor β; NFkB: Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B cells