+1 (502) 904-2126   One Westbrook Corporate Center, Suite 300, Westchester, IL 60154, USA   Site Map
ISSN: 2574 -1241

Impact Factor : 0.548

  Submit Manuscript

Mini ReviewOpen Access

Tumor Associated Macrophages (TAMs) In the World of Cancer

Volume 9 - Issue 1

Bihorac Ajna*

  • Author Information Open or Close
    • University of Belgrade, Faculty of Biology, Serbia

    *Corresponding author: Bihorac Ajna, MSc, University of Belgrade, Faculty of Biology, Department of Molecular Biology and Physiology, Serbia

Received: September 13, 2018;   Published: September 19, 2018

DOI: 10.26717/BJSTR.2018.09.001757

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF


Cancer is a disease extremely difficult to defeat. Besides tumor cells, the microenvironment is influencing progress and metastasis. Recently, it has been discovered that macrophages may promote progress of the tumors. Those tumors associated macrophages (TAMs) are still not completely defined and their role not fully described. If the phenotype of the macrophages can influence the outcome of the tumor disease, the focus should be on TAMs and their potential in development of personalized therapy in fighting metastatic tumors.

Abbreviations: TAMs: Tumor Associated Macrophages; CSF-1: Colony Stimulating Factor 1; M-CSF: Macrophage Colony Stimulating Factor; ECM: Extracellular Matrix; EGF: Epidermal Growth Factor; TNF: Tumor Necrosis Factor; VEGF: Vascular Endothelial Growth Factor; MMP: Matrix Metalloproteinases; TGFβ: Transforming Growth Factor β; NFkB: Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B cells

Abstract | Introduction | References |