*Corresponding author:Hermann S Fernandes, Divisão de Anestesia, Hospital das Clínicas, University of São Paulo, Avenida Dr. Enéas de Carvalho Aguiar, 255. 8º andar, São Paulo-SP, Brazil
Received: July 19, 2018; Published: July 26, 2018
To view the Full Article Peer-reviewed Article PDF
Background and Aims: The alpha-2-adrenergic mechanism has been explored for a long time in anesthesiology. Clonidine belongs to this class and has some interesting characteristics for this specialty.
Contents: This article illustrates pharmacological aspects, mechanisms of action and clinical use of clonidine in anesthesiology. Sedation, analgesia, lower incidence of nausea, opioid needs and adverse effects reduction are some of the beneficial effects of its use. Adverse effects are bradycardia and low blood pressure.
Conclusion: Clonidine reduces post-operative needs of opioid, pain intensity and nausea incidence. However, high risk of perioperative low blood pressure and bradycardia must be taken in consideration when deciding using this drug.