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Mini ReviewOpen Access

Tetracycline: Classification, Structure Activity Relationship and Mechanism of Action as a Theranostic Agent for Infectious Lesions-A Mini Review

Volume 7 - Issue 2

Saleha Tariq, Syed Faheem Askari Rizvi* and Ummar Anwar

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    • Department of Chemistry, Government College University Faisalabad- 38000, Pakistan

    *Corresponding author: Syed Faheem Askari Rizvi, Department of Chemistry, Government College University Faisalabad- 38000, Pakistan

Received: July 18, 2018;   Published: July 25, 2018

DOI: 10.26717/BJSTR.2018.07.001475

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Infectious diseases are a major cause of threat throughout the world which may have concern with microorganisms, specifically bacteria. Various antibiotics are synthesized and used against infectious diseases to mimic the death rate. The tetracyclines are a broad spectrum antibiotics discovered as natural products with exclusive biological and chemical properties against both gram-positive/negative bacteria. Many of members of this family also possess some non-antibacterial properties such as anti-inflammatory, immunosuppressant and inhibition of lipase. Various studies reveals structure activity relationship of the tetracycline family, which shows the bioactivity, strength and selectivity to biological target, specifically depends upon modification of lower and upper peripheral zones of tetracycline skeleton. The broad spectrum antibacterial activities of tetracyclines drag the attention toward labeling of tetracycline with radioisotopes for imaging of infectious lesions. For labeling purposes, optimization conditions, characterization, in-vivo and in-vitro studies are essential parameters to be studied. In clinical practice, tetracycline and three of its analogs were labeled with technetium-99m ( Tc-99m) used as diagnostic agents for renal and myocardial abnormalities as well as for inflammatory disorders Graphical Abstract.

Keywords: Tetracyclines; Antibacterial; Anti-Inflammatory; Immune-suppressant; Structure Activity Relationship

Abstract | Introduction | Conclusion | Acknowledgement | References |