*Corresponding author:Spelman Lynda Jane, Veracity Clinical Research: Brisbane, Australia, Queensland Institute of Dermatology: Brisbane, Australia
Received: July 12, 2018; Published: July 19, 2018
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Atopic Dermatitis (AD) is a chronic inflammatory skin disease, which occurs most often in children compared with the adult AD population . Wool is commonly considered an allergen and trigger for exacerbation of AD. However, Super Fine Merino Wool (SMW) has not been extensively studied and may show some effect in improving AD symptoms such as itch, erythema and induration. To explore this hypothesis, we performed an investigator blinded, repeated measures, self-controlled experimental design study with Super Fine Merino Base Layer Garments (SMWBG). SMWBG were worn by 29 patients with AD between the ages of 6 to 25 years over a 15 week period. We examined the tolerability and potential therapeutic effect of SMWBG (garments worn directly against the skin) in children and young adults with atopic dermatitis (AD). Response was assessed using validated scoring scales: Severity Scoring of Atopic Dermatitis (SCORAD1), Eczema Area Severty Index (EASI2), Patient-Orientated Eczema Measures (POEM3) and a non-validated Dermatitis Severity Assessment (DSA4). Wilcoxon signed-rank tests were conducted to measure the difference between garment intervention phases. Statistically significant results were observed between the pre-garment intervention phase and the with-garment interventionphases for many of the scores. Results found that SMWBG were well-tolerated in children and young adults as an adjunctive therapy for the treatment of AD. This study was conducted in Brisbane, Australia between July 2014 and October 2015 and is Human Research Ethics Committee (HREC) approved.
Keywords: Atopic Dermatitis; Clinical Trial; Adjunctive Therapy; Superfine Merino Wool Base Layer Garments
Abbreviations: AD: Atopic Dermatitis; SMW: Super Fine Merino Wool; SMWBG: Super Fine Merino wool Base Layer Garments; SCORAD: Severity Scoring of Atopic Dermatitis; EASI: Eczema Area Severty Index; DSA: Dermatitis Severity Assessment; HREC: Human Research Ethics Committee; TCS: Topical Cortico Steroids; IP: Intervention Phase; TEWL: Transepidermal Water Loss