Research ArticleOpen Access

Long Term Consumption of Ibie Leave (Mucuna Flagellipes) Diets Improves Visuo-Spatial Learning and Memory in Swiss White Mice

Volume 7 - Issue 1

**Amah*¹, AK Aduema W², Amah UK3 and Ejiofo DC¹**

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- ¹Department of Medical Physiology, Imo State University, Nigeria
- ²Department of Human Physiology, PAMO, University of Medical Sciences, Nigeria
- ³Department of Chemical Pathology, Nmandi Azikiwe University, Nigeria
*Corresponding author: Amah, Department of Medical Physiology, Imo State University Department of Human Physiology, PAMO University of Medical Sciences, Nigeria

Received: June 28, 2018; Published: July 19, 2018

DOI: 10.26717/BJSTR.2018.07.001442

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Abstract

Mucuna Flagellipes is one of the plants commonly used widely in the South Eastern part of Nigeria for the treatment of Anemia. There have never been any record authenticated to the best of my knowledge that focus on the effect of Mucuna Flagellipes on visuo-spatial learning and memory, therefore the objective of this study was to determine whether Mucuna flagellipes has effect on the above neurobehavioral parameter, using CD-1 as experimental animals. Thirty CD-1 mice were bought and randomly divided into two groups, consisting of ten (10) mice. Group 1(control) received normal rat fed whereas group 2(test) received the Mucuna diet and clean drinking water for twenty-one days. After this period, they were tested using the Morris water maze. The group 2 animals that received the Mucuna flagellipes showed improved learning and memory behavior by a significantly lower swim latency during acquisition training and reversal training (P<0.01) and (P<0.05) compared to group 1 (control). Preference to the Northwest and Southeast quadrant was statistically higher (P<0.001) compared to group 1. Annulus reversal crossing was also higher (P<0.01) when compared to group 1. In visible platform task, the test group was statistically lower (P<0.001) compared to group 1. Therefore, Mucuna Flagellipes with a fair measure of accuracy improves learning and memory and could be used in the management and treatment of retrograde amnesia.

Keywords: Mucuna Flagellipes; Morris Water; Maze; Memory; Mice; Amnesia

Abbreviations: CRC: Colorectal Cancer; TBBPS: Total Boston Bowel Preparation Scale Score; IRB: Institutional Review Board; BMI: Body Mass Index; ASA: American Society of Anesthesiologists; NP: Nurse Practitioner; PA: Physician’s Assistant; PCP: Primary Care Provider; PEG: Polyethylene Glycol