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The Effects of Antioxidants on Liver Regeneration

Volume 6 - Issue 4

**Mediha Canbek*¹ and Ayse Ozmen Yaylaci^1,2**

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- ¹Department of Biology, Eskisehir Osmangazi University, Turkey
- ²Department of Biology, Hitit University, Turkey
*Corresponding author: Mediha Canbek, Department of Biology,Eskisehir Osmangazi University, Turkey

Received: July 02, 2018; Published: July 10, 2018

DOI: 10.26717/BJSTR.2018.06.001375

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Abstract

The liver is an important organ that supports vital functions, including absorption of metabolites from theintestines,regulationof glucose and lipid metabolism, biotransformation of xenobiotics,secretionofhormonesand maintenance of osmotic balance, etc. Impairment of hepatic functions for any reason maylead to hepatic failure if not treated appropriately [1,2].Involving many complex events at both cellular andmolecular level, regeneration of the liver is usually divided into three phases [3].The “early phase” is whenthe regeneration starts with a rapid proliferation of the liver cells. It represents hepatocytestransition fromG0 phase to G1, where the number of newly expressed genes and level of genetic expression is greatlyelevated. The “transition phase” represents the occurrence of mitosis where the cells pass through G1-SG2-M phases during the cell cycle [4].

Keywords: Liver Regeneration; Antioxidants; Partial Hepatectomy; Acute Liver Injury

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