The Significance of Cerebral Comorbidities in Idiopathic Normal Pressure Hydrocephalus

Derya Kaya* and Ahmet Turan Isik

Received: June 25, 2018;   Published: July 05, 2018

DOI: 10.26717/BJSTR.2018.06.001340

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Abstract

Idiopathic normal pressure hydrocephalus (INPH) is a potentially treatable geriatric disease which mostly presented with triad of cognitive, gait and sphincter symptoms. There are many papers concerning vascular co morbidities such as diabetes mellitus, hypertension, ischemic heart disease and stroke in INPH. However, few data exist about cerebral comorbidities such as lewy body diseases, frontotemporal dementia, Alzheimer’s disease and cerebral microbleeds, and their impacts on the prognosis and patient management. This mini review aims to highlight those cerebral pathologies and their associations with INPH.

Keywords: Alzheimer’s Disease; Lewy Body Dementia; Frontotemporal Dementia; Cerebral Microbleeds; Idiopathic Normal Pressure Hydrocephalus

Abbrevations: AD: Alzheimer’s Disease; ABETA: Amyloid Beta; BVFTD: Behavioural Variant Frontotemporal Dementia; CMBS: Cerebral Microbleeds; C9ORF72: Chromosome 9 Open Reading Frame 72; FTLD: Frontotemporal Lobar Degeneration; HPTAU: Hyperphosphorylated Tau-Protein; INPH: Idiopathic Normal Pressure Hydrocephalus; LBDS: Lewy Body Diseases; MRI: Magnetic Resonance Imaging; PTS: Patients

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