*Corresponding author:
Chan Kam Tim Michael, Specialist in Dermatology, Hong Kong SAR, China. 2128, Pioneer Centre, 750, Nathan Road, Mongkok, Kowloon, Hong Kong, Hong Kong SAR, ChinaReceived: June 18, 2018; Published: June 26, 2018
DOI: 10.26717/BJSTR.2018.06.001300
To view the Full Article Peer-reviewed Article PDF
Chronic Atopic Dermatitis (AD) is inadequately managed in the primary health care and hospital settings [1,2]. Steroid phobia, emergence of methicillin resistant Staphylococcus aureus (MRSA), poor compliance to emollients therapy, inaccessibility to costly biologics and lack of effective preventive measures are all real problems to service providers taking care of children and adults suffering from this chronic distressing illness. Behavior disturbances, fear, anxiety, social isolation, stress and depression are negative emotional factors well reported associated with intractable pruritus of chronic AD [3].
Abbrevations: AD: Chronic Atopic Dermatitis; MRSA: Methicillin Resistant Staphylococcus Aureus; PNS: Peripheral Nervous System; CNS: Central Nervous System; TRP: Transient Receptor Potential; SP: Substance P; NO: Nitric Oxide;DRG: Dorsal Root Ganglion; CGRP: Calcitonin Gene Related Peptide; H1: Histamine 1; NNP: Non-Histaminergic Neuronal Pathway; PAR 2: Proteases Activated Protein; TSLP: Thymic Stromal Lymphopoietin;Ca++:CalciumCation Influx; Na+: Sodium;GRPR: Gastrin Releasing Peptide Receptor; NGF: Nerve Growth Factors; NA: Noradrenaline; IFN-ϒ: Interferon-ϒ; Nppb: Natriuretic Polypeptide b; f-MRI: Functional Magnetic Resonance Imaging; AI: Artificial Intelligence; T-DCS: Transcranial Direct Current Stimulation; R – TMS: Repetitive Transcranial Magnetic Stimulation; EMG:Electromyography
Short Communication| Existence of A Pruritogenic Specific Neuron Signalling Pathway| Pharmacological and Non-Pharmacological Implications| References|