Research ArticleOpen Access

Synthesis and Characterization of Nanoporous Hydroxyapatite with High Hemocompatibility

Volume 5 - Issue 4

Chee-Heong Ooi, Swee-Yong Pung and Fei-Yee Yeoh*

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- School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Malaysia
*Corresponding author: Fei-Yee Yeoh, School of Materials and Mineral Resources Engineering, Engineering Campus, Universiti Sains Malaysia, 14300 Nibong Tebal, Penang, Malaysia

Received: June 05, 2018; Published: June 18, 2018

DOI: 10.26717/BJSTR.2018.05.001239

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Abstract

Hydroxyapatite with nanoporous structure is a valuable biomaterial to enhance the efficiency of adsorption based biomedical applications, i.e., drug delivery and protein adsorption. In this study, nanoporous hydroxyapatite was synthesized by using hydrothermal technique. Decyltrimethylammonium bromide (C10TAB) surfactant was used as template for the formation of nanoporous structure in the hydroxyapatite. The presence of pure hydroxyapatite phase in the synthesized samples is verified by Fourier transform infrared spectroscopy. The nanoporous hydroxyapatite samples exhibit pore size of 18.5-33.5nm, BET surface area of 39.5-84.6 m2 g-1 and pore volume of 0.35-0.44 cm3g-1. The hemolysis test shows that the nanoporous hydroxyapatite samples are highly hemocompatible with the percentage of hemolysis less than 5 %. This study reveals the effectiveness of the hydrothermal technique for producing nanoporous hydroxyapatite targeted for adsorption based biomedical applications.

Keywords: Hydroxyapatite; Porous material; Calcination; Surface area; Hemolysis

Abbreviations: BET: Brunauer Emmett Teller; BJH: Barrett Joyner Halenda