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Research ArticleOpen Access

Oxidative Stress and NO Generation in Cerulein-Induced Rat Pancreatitis

Volume 4 - Issue 3

Katharina Tiemann1, Jürgen Schnekenburger2, Verena Schick3, Uta Demus4, Ursula Müller-Werdan5, Dmitri Atiakshin6, Werner Boecker1, Vera Samoilova1 and Igor Buchwalow*1

  • Author Information Open or Close
    • 1Institute for Hematopathology, Germany
    • 2Biomedizinisches Technologiezentrum der Medizinischen Fakultät, Germany
    • 3Department of Medicine B, University Hospital Muenster, Germany
    • 4Gesellschaft zurFörderungvonMedizin, Bio- und Umwelttechnologien, Germany
    • 5Chair of Geriatrics, Charité-Universitätsmedizin Berlin, and Protestant Geriatric Centre, Germany
    • 6Research Institute of Experimental Biology and Medicine, Burdenko Voronezh State Medical University, Russia

    *Corresponding author:Igor Buchwalow, Institute for Hematopathology, 22547 Hamburg, Germany

Received: May 01, 2018;   Published: May 11,2018

DOI: 10.26717/BJSTR.2018.04.001063

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Abstract

The interaction between nitric oxide (NO) and superoxide’s is critical in the development of pancreatitis. Previously, we reported on the up-regulation of oxidative stress and NO-synthase (NOS) in the human chronic pancreatitis and in an animal model of pancreatitis induced by pancreatic duct ligation (PDL) in rats. We have shown that oxidative stress runs ahead of NOS up-regulation, which implies that the NO enhancement in the course of pancreatitis is likely to be an adaptive mechanism aimed at maintaining the homeostatic cellular level of the bioactive NO. Here, we report on the expression of NOS and oxidative stress markers (nitro tyrosine and 8-hydroxyguanosine) in the course of erulean-induced acute pancreatitis in rats. We found that the pattern of superoxide’s/NO interaction in this model of acute pancreatitis is similar to that in the PDL-induced rat pancreatitis and in the human chronic pancreatitis. It means that erulean-induced acute pancreatitis like the PDL-induced pancreatitis is a proper model for further studies of pancreatitis development in humans.

Keywords: Acute Pancreatitis; Nitric Oxide Synthase; Oxidative Stress

Abstract| Introduction| Materials and Methods| Results and Discussion| References|