*Corresponding author:Chan Kam Tim Michael, Specialist in Dermatology, Hong Kong Academy of Medicine, Vice President of Integrative Aesthetic Medicine of Hong Kong, 2128, Pioneer Center, 750, Nathan Road, Mongkok, Kowloon, Hong Kong, Hong Kong SAR, China
Received: April 02, 2018; Published: April 09, 2018
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Advances in modern biomedical science and technical research give evidence that Cognitive movement disorders like Parkinson’s Disease (PD) may be closely related with gastro-intestinal dysbiosis and the production of internal toxic protein reaching the brain, skin and other organs of the body through the enteric nervous system (ENS) [1-5].Gut especially small intestinal epithelial barrier defects; which primarily function as an important first line physiological, immune and endocrine absorption organ may become aberrant as a result of genetic predisposition and western life style dietary habit. The breaking down of the epithelial cells tight junctions allows diffusions of toxins released froma modern western diet mainly composed of a high content of processed carbohydrate: high sugar and fats ratio relative to low fibres, pollutants like heavy metals, preservatives, pesticides, infections, prolonged antibiotics intake, with a low pH environment into the body circulation.
Abbreviations: PD: Parkinson’s disease; ENS: Enteric Nervous System; IBD: Inflammatory Bowel Diseases; SN: Substantia Nigra; NMP: Non- Motor Parkinsonism; GI: Include the Gastrointestinal