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An Insight into Oral Submucous Fibrosis

Volume 3 - Issue 4

Sham Kishor Kanneppady*1, Sowmya Sham Kanneppady2, Anusha Rangare Lakshman3, Shishir Ram Shetty4 and Prasanna Kumar Rao5

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    • 1Division of Oral Diagnostics and Surgical Sciences, International Medical University, Malaysia
    • 2Department of Pharmacology, Lincoln University College, Malaysia
    • 3Department of Oral Medicine and Radiology, Century International Institute of Dental Sciences and Research Centre, India
    • 4Department of Oral Medicine and Radiology, Gulf Medical University, UAE
    • 5Department of Oral Medicine and Radiology, AJ Institute of Dental Sciences, India

    *Corresponding author: Sham Kishor Kanneppady, Senior Lecturer, Division of Oral Diagnostics and Surgical Sciences, School of Dentistry, International Medical University, Kuala Lumpur, Malaysia

Received: March 21, 2018;   Published: April 06, 2018

DOI: 10.26717/BJSTR.2018.03.000924

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Oral submucous fibrosis (OSF) is a chronic, progressive, scarring, precancerous condition which is characterized by mucosal rigidity. It clinically appears as blanching of oral mucosa, which is usually associated with burning sensation. On palpation of the affected mucosa, clinician may elicit fibrotic bands. The other clinical signs and symptoms of OSF are vesicles, ulcerations, petechiae, melanoses, xerostomia and limitation in jaw movement [1,2]. It has been associated with long-lasting dipping of betel nut or paan in the mouth. Oral submucous fibrosis predominantly occurs in Indians and Southeast Asians. This condition is more common in young adults, aged 20-40. The most frequently affected sites in the oral cavity are buccal mucosa, retromolar area, tongue and soft palate. Mehrotra highlighted clinical grading of the disease as follows [3].

Abbreviations: OSF: Oral Submucous Fibrosis; CTGF: Connective Tissue Growth Factor; ROS: Reactive Oxygen Species

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