An Insight into Oral Submucous Fibrosis

Sham Kishor Kanneppady*¹, Sowmya Sham Kanneppady², Anusha Rangare Lakshman³, Shishir Ram Shetty⁴ and Prasanna Kumar Rao⁵

Received: March 21, 2018;   Published: April 06, 2018

DOI: 10.26717/BJSTR.2018.03.000924

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF

Abstract

Oral submucous fibrosis (OSF) is a chronic, progressive, scarring, precancerous condition which is characterized by mucosal rigidity. It clinically appears as blanching of oral mucosa, which is usually associated with burning sensation. On palpation of the affected mucosa, clinician may elicit fibrotic bands. The other clinical signs and symptoms of OSF are vesicles, ulcerations, petechiae, melanoses, xerostomia and limitation in jaw movement [1,2]. It has been associated with long-lasting dipping of betel nut or paan in the mouth. Oral submucous fibrosis predominantly occurs in Indians and Southeast Asians. This condition is more common in young adults, aged 20-40. The most frequently affected sites in the oral cavity are buccal mucosa, retromolar area, tongue and soft palate. Mehrotra highlighted clinical grading of the disease as follows [3].

Abbreviations: OSF: Oral Submucous Fibrosis; CTGF: Connective Tissue Growth Factor; ROS: Reactive Oxygen Species

Introduction| Conclusion| References|