Combinatorial Regulatory Networks Provide Novel Biomarkers for Diagnosis and Therapeutics

Esra Gov*

Received: March 09, 2018;   Published: March 21, 2018

DOI: 10.26717/BJSTR.2018.03.000879

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Abstract

One the most important discoveries of the post-genomic era is that a large fraction of the genome transcribes a heterogeneous population of non-coding RNAs (ncRNA). NcRNAs shorter than 200 nucleotides are usually identified as short/small ncRNAs - examples include PIWI-interacting RNAs, small interfering RNAs, and microRNAs (miRNAs)-whereas those longer than 200 nucleotides are classified as long ncRNAs (lncRNAs). They are part a crucial role in RNA silencing and post-transcriptional regulation of gene expression [1]. These molecules are emerging as important regulators of cellular process, such as development, differentiation, and metabolism [2]. Long and short ncRNAs not only regulate developmental processes and cell physiology, but also involved in disease states, host-pathogen interactions, and a variety of stress responses [3]. Transcriptional regulation of gene expression is often the prior process due to response of system changes, wherein the information contained in a genome is converted and then ultimately used to produce the proteins required for a given response.

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