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Review ArticleOpen Access

Does Incorporation of Silicon Increases Lipophilicity? A Theoretical Perspective

Volume 3 - Issue 1

Lakhya J Mazumder, Chayanika Kashyap, Sabnam S Ullah and Ankur K Guha*

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    • Department of Chemistry, Cotton University, India

    *Corresponding author: Ankur K Guha, Department of Chemistry, Cotton University, Guwahati, Assam, India

Received: February 27, 2018;   Published: March 08, 2018

DOI: 10.26717/BJSTR.2018.03.000835

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Quantum chemical calculations have been carried out using MP2/6-311++G** level of theory to calculate lipophilicity, i.e., octanol-water partition coefficient (LogP) of some alcohols and their silicon derivatives. Very good correlation has been obtained between the experimental LogP values against our calculated one. Moreover, incorporation of Si atom into the C atom attached to the -OH group dramatically increases the lipophilicity of the compounds. This finding may have wide implications towards designing new Si incorporated drugs.

Abstract| Introduction| Results and Discussions| Conclusion| Acknowledgement| References|