HCMV-Specific Immune Monitoring in Solid Organ Transplant Recipients

Irene Cassaniti^1,2 and Fausto Baldanti^1,2*

Received: February 02, 2018;   Published: February 20, 2018

DOI: 10.26717/BJSTR.2018.02.000776

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF

Abstract

Solid organ transplant recipients (SOTRs) are at high risk of viral opportunistic infections, especially during the first six months posttransplant. Human cytomegalovirus (HCMV) remains one of the most important pathogens in transplant recipients, despite the great efforts in diagnosis and effective antiviral therapies. Immunological monitoring could be useful in order to guarantee a better management of the patients. In this setting, several methods have been employed. The review summarizes the most important approaches in immunological monitoring of HCMV-specific T-cell response in transplant setting.

Keywords: Human cytomegalovirus; Transplant; T-cell response; Quantiferon; Elispot assay

Abbreviations: SOTR:Solid Organ Transplant Recipients; HCMV: Human Cyto Megalo Virus, IFNγ: interferon gamma

Abstract| Introduction| Acknowledgment| References|