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ISSN: 2574 -1241
ISSN: 2574 -1241
Received: February 04, 2018; Published: February 15, 2018
DOI: 10.26717/BJSTR.2018.02.000765
H2-calponin, an actin-cytoskeleton associated protein, is expressed in smooth muscle and certain non-muscle cells. Researchers have demonstrated that H2-calponin proteins are highly expressed in developing and remodeling tissues. As a mechanical tension responsive gene inside the cell, H2-calponin interacts with F-actin and certain focal adhesion proteins, modifies cytoskeleton function, takes part in mechanochemical signal transmission and plays an important role in cell proliferation, differentiation, motility and cytokinesis. Based on recent research progresses in this field, this paper reviewed the molecular characteristics of H2-calponin and the role of H2-calponin in mechano sensation and mechano transduction.
Keywords: H2-calponin; Cytoskeleton; Mechano transduction; Mechanical stress
International Association of Landscape Archaeology, Czech Glass Society, Czech Republic
Department of Chemistry, Semenov Institute of Chemical Physics, USSR Academy of Sciences, Moscow, Russia
Pharmaco-kinetics, dynamics and Drug Metabolism, Touro College of Pharmacy, USA
Professor of Nuclear Medicine, Faculty of Medicine and Surgery, University of Milan, Milan, Italy
Associate Professor at Department of Breast and Thyorid Surgey, Chongqing General Hospital, China
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