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The Role of Calponin in Cell Mechano transduction

Volume 2 - Issue 3

Zhiping Miao and Airong Qian*

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    • School of Life Sciences, Northwestern Polytechnic University, Xi’an, China

    *Corresponding author: Airong Qian, School of Life Sciences, Northwestern Polytechnic University, China

Received: February 04, 2018;   Published: February 15, 2018

DOI: 10.26717/BJSTR.2018.02.000765

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H2-calponin, an actin-cytoskeleton associated protein, is expressed in smooth muscle and certain non-muscle cells. Researchers have demonstrated that H2-calponin proteins are highly expressed in developing and remodeling tissues. As a mechanical tension responsive gene inside the cell, H2-calponin interacts with F-actin and certain focal adhesion proteins, modifies cytoskeleton function, takes part in mechanochemical signal transmission and plays an important role in cell proliferation, differentiation, motility and cytokinesis. Based on recent research progresses in this field, this paper reviewed the molecular characteristics of H2-calponin and the role of H2-calponin in mechano sensation and mechano transduction.

Keywords: H2-calponin; Cytoskeleton; Mechano transduction; Mechanical stress

Abstract| Introduction| Conclusion| References|