Keratoconusis a progressiveeye disease, whichdiscloses in adolescence and usuallystabilizes in thefourthorfifthdecadeoflife. Theprogressivethinningofcorneal
stroma in which the cornea has a conical shapeleads to high irregular a stigmatism and consequently to a significantvisualacuitydecrease.
Anymethod to curethediseasehas beendeveloped up to thisday. Corneal collagen cross-linking (CXL) is the first treatment
that halts the progression of keratoconus. Cross-linkingconducted in the early stages of keratoconus allows to stop cornealchangesduring early
grade, easier to opticalcorrection. From the times of “Dresden Protocol” until now, multiple variations of the standard procedure technique
have been introduced and consistent improvement is still being searched for.Not onlydoesthe study presenttheclassicalmethodof CXL, acceleratedand
transepithelial CXL modifications, but thelatestresearchabouttheireffectiveness as well.