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Research ArticleOpen Access

An In-Vitro Study to Find the Antibiotic Susceptibility of Aggregatibacter Actinomycetocomitans to Various Antibiotics

Volume 2 - Issue 2

B Manovijay*, R Saranyan, G Balaji Babu, A Anitha and I Nithya

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    • Department of periodontics, Vinayaka mission’s sankrachariyar dental college and hospital, India

    *Corresponding author: B Manovijay, Department of periodontics, vinayaka missions sankrachariyar dental college and hospital, Ariyanoor, Salem, Tamilnadu, India

Received: January 22, 2018;   Published: February 02, 2018

DOI: 10.26717/BJSTR.2018.02.000724

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Aim: Aggregatibacter actinomycetocomitans,a gram negative facultative anaerobic coccobacilli is the main etiologic agent in the pathogenesis of localized aggressive periodontitis. So considering this, the aim of the present study was to study the sensititivity of the organism to various drugs in vitro.

Materials and Methods: Microbial plaque samples from 40 patients who were diagnosed to have localized aggressive periodontitis were cultured anaerobically to confirm Aggregatibacter actinomycetocomitans. Doycycline, amoxicillin, kanamycin, norfloxacin, ciprofloxacin, gentamycin, netilmycin co-trimoxazole, metronidazole, and ampicillin and cephazolin antibiotic sensitivity discs were placed in the culture plate. The plates were incubated anaerobically at 37 degree Celsius for 48 hours. At the end of the duration the plates were opened and the sensitivity of the organism to various drugs was examined.

Results: The antibiotic sensitivity test showed that the organism was found to be highly sensitive to tetracycline, amoxicillin, metronidazole, kanamycin, norfloxacin, ciprofloxacin, gentamycin and netilmycin. It was moderately sensitive to Co-Trimoxazole and resistant to ampicillin and Cephazolin.

Conclusion: The above results have shown the sensitivity of A.a to vaious drugs. Thus the synergisitic use of antibiotics along with periodontal surgery might improve the periodontal health in localised aggressive periodontitis patients.

Keywords: Aggregatibacter actinomycetocomitans; Aggressive periodontitis; Antibiotics; Sensitivity

Abstract| Introduction| Materials and Methods| Results| Discussion| Conclusion| References|