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Review ArticleOpen Access

Bioactive Factors in Breast Milk: The Impact on Nutritional Programming of Childhood Obesity

Volume 1 - Issue 7

Fei Xiong1,2 and Meng Mao*1

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    • 1Department of Pediatrics, West China Second University Hospital, Sichuan University, China
    • 2Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, China

    *Corresponding author: Meng Mao, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Email:

Received: December 12, 2017;   Published: December 20, 2017

DOI: 10.26717/BJSTR.2017.01.000614

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The concept of “nutritional programming” has led us to realize that early nutrition and metabolism have a very important impact on long-term health. There is a certain correlation between the growth of fetal and childhood and the occurrence of metabolic diseases in adults, such as obesity, type 2 diabetes, hypertension, and cardiovascular disease. Obesity is the most common metabolic disease whose prevalence is increasing worldwide. Nutrition in early stages of growth may be essential in the development of obesity in adulthood. Human milk is the most natural and ideal food for the baby. Moreover, breast-feeding appears to be associated with a lower risk of obesity than formula feeding. Human milk contains bioactive components, such as leptin, adiponectin, ghrelin, which are involved in food intake regulation and energy balance. These bioactive factors may contribute to childhood growth. In this review, we discuss bioactive factors contained in human milk and their potential protective effect on subsequent obesity.

Keywords : Breastfeeding; Obesity; Bioactive factors

Abbreviations: BMI: Body Mass Index; BF: Breast-Fed; SGA: Small for Gestational Age; AGA; Appropriate for Gestational Age; LGA: Large for Gestational Age; IGL: Insulin Like Growth Factor

Abstract| Introduction| Conclusion and Perspective| References|