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Postmastectomy Hypo Fractionated Radiotherapy: May be a Breakthrough in Breast Cancer Management

Volume 1 - Issue 4

Bader Abdelmaksoud* and Mostafa Toam

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    • Department of clinical oncology and nuclear medicine, Zagazig University, Egypt

    *Corresponding author: Bader Abdelmaksoud, Department of clinical oncology and nuclear medicine, faculty of medicine, Zagazig university, Egypt

Received: September 05, 2017;   Published: September 12, 2017

DOI: 10.26717/BJSTR.2017.01.000350

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Hypo fractionated schedules deliver greater than 2 Gy of radiation per fraction while reducing the total cumulative dose through reducing the number of treatment sessions. In breast cancer, radiotherapy is indicated for all patients after breast conservative surgery and for patients after mastectomy if indicated. Radio biologically, this approach appears to be as effective and safe as the conventional regimen in both experimental and clinical studies, based on the LQ model, when the α/β ratio of the tumor is similar to that of the surrounding normal tissue, the hypo fractionated regimen may be equally or potentially more effective than that of the conventional one. Conventional fractionated radiotherapy has been challenged by patient’s compliance, travelling, unplanned interruption and others compared to hypo fractionated regimen which would be more appealing and convenient to the patients, and financially, this treatment schedule is useful in reducing the radiotherapy costs. It is thought that if these schedules found to have an equivalent loco regional control, survival and cosmoses to standard conventional schedules, it would be a revolutionary breakthrough in the future for breast cancer management as if these schedules are established, it will be a major breakthrough as it will decrease the waiting list and the number of hospital visits in several cancer centers especially in the developing countries.

Keywords: Hypo Fractionation; Breast Cancer; Post Mastectomy Radiotherapy

Abstract| Introduction| Radiobiological Aspects| Conclusion| References|