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Alterations in Cellular Cholesterol Content Can Be a Potential Anticancer Strategy

Jui-Ling Hsu and Jih-Hwa Guh*

DOI: 10.26717/BJSTR.2017.01.000319

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    • School of Pharmacy, National Taiwan University, Taiwan
    • Corresponding author: Jih-Hwa Guh, School of Pharmacy, National Taiwan University, No. 33, Linsen S. Rd., Taipei 100, Taiwan

Received: August 29, 2017;   Published: August 31, 2017

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Abstract

Cholesterol, a unique lipid molecule biosynthesized by all animal cells, is an essential structural constituent in cell membranes to maintain their structural integrity and fluidity. Cholesterol is critical to synthesis of hormones, vitamin D and bile acid, multiple cellular signaling, intracellular transport and a variety of cell functions [1,2]. Cholesterol is necessary to the structure and function of caveolae and clathrin-coated pits, enabling the endocytotic activity [3,4].

|Abstract| |Introduction| |Deregulation of cellular cholesterol homeostasis by cell survival related kinases| |Major platforms of lipid rafts in organizing multiple cellular survival signals and coupling between membrane microenvironment and drug resistance| |Anticancer strategies by using cholesterol-depleting or lipid raft-modulating agents| |Conclusion| |References|