Corresponding author:Dra Mirta D’Ambra, Chairman of the World Academy of Medical Sciences, Ministry of Health, Buenos Aires University Argentina, South America
Received: August 11, 2017; Published: August 17, 2017
To view the Full Article Peer-reviewed Article PDF
Chromosome X Fragile is the prevalent hereditary cause of intellectual disability. It is an inherited disease linked to the X chromosome, Fragile X syndrome (S X F). Its main clinical manifestation is intellectual disability and affects mainly males, with a prevalence of 1/4000 and females 1/6000. Women are the transmitters. The cause is a mutation on chromosome X9 27.3 and consists of an abnormal expansion of the trinucleotide citicin-guanine-guanine (CGG) in the FMR 1 gene (Fragile X Mental Retardation) in an area not coded at the beginning of the gene.